Brand Name : VERTINORM
Generic Name : Cinnarizine
Preparation : 25 mg Tablet
Pharmacological Categories : Antihistaminics, Anti-emetics, Calcium Channel Blocker

Mechanism of Action (MOA)
VERTINORM (Cinnarizine) inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. VERTINORM has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors and muscarinic acetylcholine receptors.


  • Absorption : Absorbed from the gastrointestinal tract
  • Peak Plasma Concentration : 2 to 4 hours
  • Metabolism : Liver
  • Elimination Half-life : 3 to 6 hours
  • Excretion : Urine, faeces

Indications and Dosage

  • Peripheral Vascular Disorders : Three tablets of VERTINORM 2 or 3 times daily
  • Cerebrovascular Disorders : Three tablets of VERTINORM 1 to 3 times daily
  • Vertigo and Vestibular Disorders : One tablet of VERTINORM three times a day or three tablets of VERTINORM 1or 2 times daily
  • Motion Sickness :
    Adults : One tablet of VERTINORM taken half an hour before the start of the journey, then one tablet of VERTINORM may be repeated every 6 hours.

Side Effects
Little drowsiness, less sedation, little antimuscarinic effect, nausea, vomiting, diarrhoea, epigastric pain, palpitations, arrhythmias, hypersensitivity reaction, agranulocytosis, leucopenia, haemolytic anaemia, thrombocytopenia, convulsions, sweating, myalgia, paresthesia, rare extrapyramidal effects, depression, confusion, hypotension

Hypersensitivity to cinnarizine, Parkinson’s disease

Warnings / Precautions

  • Caution in patients with hypotension, during pregnancy and breastfeeding.
  • Do not drive a car or operate machinery.

Drug Interactions

  • Cinnarizine may enhance the sedative effect of central nervous system depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics so should be avoided in excess.

Pregnancy Category : C

VERTINORM 25 mg : A box of 10 strips, each strip of 10 tablets