Brand Name : NEUROTONE
Generic Name : Thiamine HCl
Preparation : 100 mg Tablet
Pharmacological Category : Vitamin B1
Mechanism of Action (MOA)
NEUROTONE (Thiamine) combines with adenosine triphosphate (ATP) to form thiamine pyrophosphate also known as cocarboxylase. This is an essential coenzyme in carbohydrate metabolism.
- Absorption : Absorbed adequately from the gastrointestinal tract
- Distribution : Distributes mainly to heart, brain, kidney and liver
- Excretion : Urine
Indications and Dosage
- Thiamine Deficiency :
Mild : One tablet of NEUROTONE 100 mg daily;
Severe Deficiency : Two to three tablets of NEUROTONE 100 mg daily in divided doses for one month.
- Alcohol Withdrawal Syndrome : 100 mg/day IV or IM for several days followed by one tablet of NEUROTONE 100 mg daily orally
- Wernicke’s encephalopathy : 500 mg IV with other vitamins every 8 hours, for 2 days if symptoms persist, and followed by one tablet of NEUROTONE 100 mg three times a day up to three months
- Primary Dysmenorrhea (Menstrual Cramps) : One tablet of NEUROTONE 100 mg per day for 3 months
Warmth, anaphylaxis, cyanosis, diaphoresis, restlessness, angioneurotic edema, pruritus, urticaria, pulmonary edema, weakness, tightness of the throat, nausea (frequency not defined)
Hypersensitivity to thiamine
Warnings / Precautions
- Administer dextrose cautiously when thiamine status is uncertain as acute thiamine deficiency has been reported with dextrose administration.
- Evaluate for the additional vitamin deficiencies if patient is diagnosed with thiamine deficiency as single vitamin deficiencies are rare.
- Thiamine possibly enhances the action of neuromuscular blocking agents eg. pancuronium, vecuronium.
- Thiamine may interfere various tests like Schack and Waxler determination of serum theophylline concentrations, phosphotungstate method for the test of uric acid and test for urobilinogen using Ehrlich’s reagent.
Pregnancy Category : A
NEUROTONE 100 mg : A box of 10 strips, each strip of 10 tablets