Brand Name : SAMLOD
Generic Name : S-amlodipine besylate
Preparations : 2.5 mg / 5 mg Tablets
Pharmacological Categories : Calcium Channel Blocker / Antihypertensive / Antianginal
Mechanism of Action (MOA)
SAMLOD (S-amlodipine) is the active enantiomer of amlodipine. SAMLOD blocks the transmembrane influx of calcium into the vascular smooth muscle and cardiac muscle through L-type calcium channel resulting in vasodilation and hence lowers blood pressure. Dilation of coronary arteries helps to increase the delivery of oxygen to the myocardial tissues in patients with vasospastic angina.
Pharmacokinetics
- Absorption : Absorbed from the gastrointestinal tract
- Peak Plasma : 2 to 3 hours
- Protein Binding : Approximately 93%
- Metabolism : Liver
- Elimination Half-life : 49.6 hours
- Excretion : Kidney
Indications and Dosage
- Hypertension
- Angina
Dose : SAMLOD 2.5 to 5 mg once daily
Side Effects
Edema, flushing, headache, aspartate aminotransferase or alanine aminotransferase elevation, chest pain, dizziness, fatigue, gastrointestinal disturbances, palpitations, lymphocytic panniculitis
Contraindications
Liver insufficiency, pregnancy
Warnings / Precautions
- Lactation, heart failure, hepatic impairment
- May increase frequency and / or severity of angina during treatment initiation or dosage increments
Pregnancy Category : C
Presentations
SAMLOD 2.5 mg : A box of 10 blisters, each blister of 15 tablets
SAMLOD 5 mg : A box of 10 blisters, each blister of 15 tablets
