Brand Name : HYOSPAN
Generic Name : Hyoscine Butylbromide
Preparation : 10 mg Tablet
Pharmacological Categories : Antispasmodic, Antimuscarinic, Anticholiergic

Mechanism of Action (MOA)
HYOSPAN blocks the action of acetylcholine at parasympathetic sites in smooth muscles of gastrointestinal, biliary and urinary tracts and secretory glands.
HYOSPAN is quaternary ammonium compound that does not cross blood brain barrier. Thus, HYOSPAN has rare central side effects.


  • Absorption : Partially absorbed following oral administration (8%)
  • Bioavailability : Less than 1%
  • Protein Binding : Low
  • Metabolism : Liver
  • Elimination Half-life : Approximately 5 hours
  • Excretion : Via urine 50% (as metabolites)

Indications and Dosage
Smooth Muscle Spasm (Non Specific Colicky Abdominal Pain, Billiary Colic, Renal Colic, Dysmenorrhoea, Adjunctive Relief in Cancer Pain and Radiological and Diagnostic Endoscopy of Gastrointestinal Tract) : Two tablets of HYOSPAN four times a day
Irritable Bowel syndrome : One tablet of HYOSPAN three times a day, increased if required to two tablets of HYOSPAN four times a day

Side Effects
MOST COMMON : Blurred vision, photophobia, increased intraocular pressure, dry nose, bronchospasm (occasional), tachycardia, palpitation, constipation, xerostomia, dry throat, urinary retention

Myasthenia gravis, megacolon, untreated narrow angle glaucoma, tachycardia, hypertrophy of the prostate with urinary retention and mechanical stenoses of the gastrointestinal tract

Warnings / Precautions

  • Caution in Down’s syndrome, children, and the elderly.
  • Caution in gastro-oesophageal reflux disease, diarrhoea, ulcerative colitis, autonomic neuropathy, acute myocardial infarction, hypertension, conditions characterized by tachycardia (including hyperthyroidism, cardiac insufficiency, cardiac surgery), pyrexia, and in individuals susceptible to angle-closure glaucoma.

Drug Interactions

  • When hyoscine is given with alcohol or other CNS depressants, it may enhance the sedative effects of those drugs.
  • The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by hyoscine.
  • Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract.
  • The tachycardic effects of beta-adrenergic agents may be enhanced by hyoscine.

Pregnancy Category : C

HYOSPAN 10 mg : A box of 20 strips, each strip of 10 tablets