Brand Name : DOBSIL
Generic Name : Calcium Dobesilate
Preparation : 500 mg Capsule
Pharmacological Categories : Vasculoprotector, Venotonic
Mechanism of Action (MOA)
DOBSIL has a comprehensive mode of action.
DOBSIL acts on the endothelial layer and basement membrane of the capillaries. DOBSIL increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase, decreasing capillary hyper-permeability. The histamine and bradykinin induced hyperpermeability and capillary fragility is reduced and red blood cell membrane flexibility is increased.
DOBSIL shows antiplatelet and fibrinolytic activity by inhibiting platelet activation factor (PAF) and enhancing the release of tissue plasminogen activator (tPA), thereby improving the local blood flow to tissue, otherwise inhibited due to thrombosis.
DOBSIL also inhibits the two pathophysiological reactions in diabetes via polyol pathway and glycation of proteins due to its inhibitory effects on aldose reductase. DOBSIL may also inhibit the formation of sorbitol, thus providing another possible mechanism for its usefulness in diabetic retinopathy.
- Absorption : Fully absorbed from the gastrointestinal tract
- Time to Peak Concentration : 6 hours
- Protein Binding : 20 to 25%
- Elimination Half-life : 2.5 to 15 hours
- Excretion : Urine (50%) and faeces (50%)
Indications and Dosage
- Diabetic Retinopathy : Two capsules of DOBSIL twice daily for 24 months
- Haemorrhoids : One capsule of DOBSIL twice daily for 1 week then 1 capsule of DOBSIL once daily for 5 weeks
- Chronic venous diseases : One capsule of DOBSIL twice daily for 3 months
Fever, gastrointestinal disorders, arthralgia, agranulocytosis
Hypersensitivity to calcium dobesilate, first trimester pregnancy, lactation
Warnings / Precautions
- Caution in patients with duodenal or peptic ulcer, recurrent gastritis.
- In case of severe renal insufficiency requiring dialysis, the dose should be reduced.
Pregnancy Category : C
DOBSIL 500 mg : A box of 10 blisters, each blister of 10 capsules