Brand Name : ELYTE
Pharmacological Category : Oral Rehydration Salts (ORS)
Each sachet of ELYTE contains
Sodium chloride IP 2.6 g
Potassium chloride IP 1.5 g
Sodium citrate IP 2.9 g
Dextrose (anhydrous) IP 13.5 g
Concentration in mOsmol/litre
Total Osmolarity 245
Method of Preparation
- Dissolve the entire content of “ELYTE” in 1 liter of boiled and cooled drinking water.
- Do not boil the solution.
- Always use freshly prepared “ELYTE” solution. The prepared solution should be consumed within 24 hours.
Mechanism of Action (MOA)
Dehydration occurs when the body loses more fluid than it takes in. In cases of dehydration sodium regulation cannot work effectively.
Oral rehydration solution provides the balanced mixture of glucose, electrolytes and salts. The intestinal wall consists of a “sodium-glucose co-transporter,” a protein that absorbs salt much better in the presence of glucose. Glucose facilitates the absorption of sodium on a 1:1 molar basis. During this sodium absorption stage, water molecules are also absorbed helping the body to rehydrate.
Citrate corrects the metabolic acidosis caused by diarrhoea and dehydration.
Potassium in the solution replaces normal serum concentrations of potassium.
Additionally, oral rehydration solution has osmolarity slightly less than that of plasma making the therapy most effective.
- In patients with dehydration associated with acute diarrhoea of various etiologies.
Based on body-weight and the severity of the condition the dosage of the prepared solution is decided. Since the initial aim of treatment is to rehydrate the patient, and, subsequently, to maintain hydration by replacing any further losses due to continuing diarrhoea and vomiting. Initial rehydration should be rapid, over 3 to 4 hours. If the patient is hypernatremic, rehydration over 12 hours is appropriate.
For adults : 200 to 400 ml of oral rehydration solution for every loose motion
For children: 200 ml for every loose motion
For infants: 1 to 1.5 times their usual feed volume
After correcting the initial fluid deficit normal feeding can be continued. In case of baby breast feeding should be continued between administrations of oral rehydration solution.
• Vomiting can occur indicating that ORS was given too quickly. If vomiting occurs, administration should be halted for 10 minutes then resumed in smaller, more frequent, amounts.
• Overdosage of ORS in patients with renal impairment may lead to hypernatremia and hyperkalaemia.
• Oral rehydration salts should be reconstituted only with water and at the volume stated.
• Fresh drinking water is generally appropriate, but freshly boiled and cooled water is preferred when the solution is for infants or when drinking water is not available.
• The solution should not be boiled after it is prepared.
• Other ingredients such as sugar should not be added.
• Unused solution should be stored in a refrigerator and discarded within 24 hours of preparation.
• Oral rehydration solutions are not appropriate for patients with gastrointestinal obstruction, oliguric or anuric renal failure, or when parenteral rehydration therapy is indicated as in severe dehydration or intractable vomiting.
ELYTE : A box of 50 sachets